Technology
The Uniz Lab is committed to continuous monitoring
and research to ensure formulation stability for the physical and chemical stability of spicules
Technology
The Uniz Lab is committed to continuous monitoring and research to ensure formulation stability for the physical and chemical stability of spicules
Extraction
Microbial enzymes and solvents separate spicules in different ways.
Fermentation and chemical extraction are both methods used to isolate desired compounds from natural sources, but they differ in process and principle. Fermentation extraction utilizes microbial enzymes to break down organic matter and generate new substances, whereas chemical extraction uses solvents to dissolve and separate target compounds. Our laboratory has developed a proprietary, eco-friendly method to extract spicules from sponges. This fermentation-based technique breaks down sponge tissue using microbial enzymes to obtain spicules. Compared to chemical extraction, it operates under milder conditions and is recognized as a sustainable alternative.
Fermentation Extraction
Definition
A method of obtaining useful components by decomposing substances and creating new substances using microorganisms (mainly yeast, mold, and bacteria).
Principle
Enzymes found in microorganisms break down substrates (raw materials) to produce specific components or change the structure of existing materials to increase their usefulness.
Merit
• It can better utilize the active ingredients of natural ingredients.
• It can create new bioactive substances.
• Some fermentation processes help digestion and absorption of food and increase storage capacity.
• It is environmentally friendly because it does not use chemical solvents.
Disadvantage
• The fermentation process is complex and can take a long time.
• Controlling the fermentation environment (temperature, pH, nutrients, etc.) is important, and if it fails, it is difficult to obtain the desired substance.
• The production speed can be slower than chemical extraction.
Example
Manufacturing of fermented foods such as kimchi, yogurt, and cheonggukjang, and enhancing effective ingredients through fermentation of plant extracts, etc.
Chemical Extraction
Definition
A method of dissolving and separating substances using a solvent.
Principle
Separation is achieved by taking advantage of the property of the desired substance to dissolve well in a solvent.
Merit
• It can separate substances in a shorter time than fermentation extraction.
• Generally easy for mass production.
Disadvantage
• There is a possibility of environmental pollution because chemical solvents are used.
• Harmful substances may be generated.
• Sometimes, unwanted substances may be extracted along with the desired substances.
Example
Plant extraction using organic solvents, production of petrochemical products, etc.
Extraction
Extraction Method
Microbial enzymes and solvents separate spicules in different ways.
Fermentation and chemical extraction are both methods used to isolate desired compounds from natural sources, but they differ in process and principle. Fermentation extraction utilizes microbial enzymes to break down organic matter and generate new substances, whereas chemical extraction uses solvents to dissolve and separate target compounds. Our laboratory has developed a proprietary, eco-friendly method to extract spicules from sponges. This fermentation-based technique breaks down sponge tissue using microbial enzymes to obtain spicules. Compared to chemical extraction, it operates under milder conditions and is recognized as a sustainable alternative.
Fermentation Extraction
Definition
A method of obtaining useful components by decomposing substances and creating new substances using microorganisms (mainly yeast, mold, and bacteria).
Principle
Enzymes found in microorganisms break down substrates (raw materials) to produce specific components or change the structure of existing materials to increase their usefulness.
Merit
• It can better utilize the active ingredients of natural ingredients.
• It can create new bioactive substances.
• Some fermentation processes help digestion and absorption of food and increase storage capacity.
• It is environmentally friendly because it does not use chemical solvents.
Disadvantage
• The fermentation process is complex and can take a long time.
• Controlling the fermentation environment (temperature, pH, nutrients, etc.) is important, and if it fails, it is difficult to obtain the desired substance.
• The production speed can be slower than chemical extraction.
Example
Manufacturing of fermented foods such as kimchi, yogurt, and cheonggukjang, and enhancing effective ingredients through fermentation of plant extracts, etc.
Chemical Extraction
Definition
A method of dissolving and separating substances using a solvent.
Principle
Separation is achieved by taking advantage of the property of the desired substance to dissolve well in a solvent.
Merit
• It can separate substances in a shorter time than fermentation extraction.
• Generally easy for mass production.
Disadvantage
• There is a possibility of environmental pollution because chemical solvents are used.
• Harmful substances may be generated.
• Sometimes, unwanted substances may be extracted along with the desired substances.
Example
Plant extraction using organic solvents, production of petrochemical products, etc.
Differences by Extraction
Features | Fermentation Extraction | Chemical Extraction |
| Efficiency | Varies depending on conditions, can be slow | Generally high and fast |
| Cost | Cost of media and system construction can be high | Reagents are inexpensive, energy and waste disposal costs may be high |
| Safety (Operator) | Relatively safe | Caution is required when handling corrosive chemicals |
| Safety (Product) | No risk of residual chemicals | Risk of residual chemicals |
| Environmental friendliness | Relatively environmentally friendly | High potential for hazardous waste |
| Extract purity | Can be pure due to enzyme specificity | Possible for contamination, may require additional purification |
| Preservation of spicule structure | Structure preservation can be advantageous under mild conditions | Possible for damage under harsh conditions |

UNIZ LAB CEO : Youngran Joo
2F, Building 2, 381 Aenggogae-ro, Namdong-gu, Incheon, South Korea
Tel : +82-70-4109-6722
Fax : +82-32-811-7678
E-mail : uniz@uniz.co.kr
© UNIZ LAB. All rights reserved..

UNIZ LAB CEO : Youngran Joo 2F, Building 2, 381 Aenggogae-ro, Namdong-gu, Incheon, South Korea
Tel : +82-70-4109-6722 Fax : +82-32-811-7678 E-mail : uniz@uniz.co.kr
© UNIZ LAB. All rights reserved.